Nicotinamide Riboside Benefits

Nicotinamide Riboside Benefits

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Every human body uses Nicotinamide Riboside (NR) every day for basic functions like sleeping, breathing, eating, and drinking. It declines under stress and over time which contributes to changes in health. Because this molecule is important for basic mitochondrial function, it impacts every cell in the body. Similar to Resveratrol, when we supplement with NR, we see benefits universally.  Most companies sell it as a standalone product, very expensive, but with Natural Biology's philosophy of using cutting edge research and being an exception value, we added it to two of our most extensive formulas:  EVEREST Earth & Sea Formula & OxyAGE - at research potencies.  If you take both products you will receive a full therapeutic dosage of NR.  



Within your body, nicotinamide riboside is converted into NAD, a helper molecule that exists inside each of your cells and supports many aspects of healthy cells.  These are the primary benefits:

  • Converting food into energy
  • Repairing damaged DNA
  • Fortifying cells’ defense systems
  • Setting your body’s internal clock or circadian rhythm

May Help Protect Brain Cells

NR converted in your body to NAD plays a key role in helping your brain cells age well.

Within brain cells, NAD helps control the production of PGC-1-alpha, a protein that appears to help protect cells against oxidative stress and impaired mitochondrial function (15Trusted Source).

Researchers believe both oxidative stress and impaired mitochondrial function are linked to age-related brain disorders such as Alzheimer’s and Parkinson’s disease (16Trusted Source, 17Trusted Source, 18Trusted Source).

In mice with Alzheimer’s disease, nicotinamide riboside raised brain NAD levels and PGC-1-alpha production by up to 70% and 50%, respectively. By the end of the study, the mice performed significantly better in memory-based tasks (4Trusted Source).

In a test-tube study, nicotinamide riboside raised NAD  levels and significantly improved mitochondrial function in stem cells taken from a Parkinson’s disease patient (19Trusted Source).

However, it’s still not clear how helpful it is to raise NAD levels in people with age-related brain disorders. More human studies are needed.

May Lower Heart Disease Risk

Aging is a major risk factor for heart disease, which is the world's leading cause of death (20Trusted Source).

It can cause blood vessels like your aorta to become thicker, stiffer and less flexible.

Such changes can raise blood pressure levels and make your heart work harder.

In animals, raising NAD helped reverse age-related changes to arteries (21Trusted Source).

In humans, nicotinamide riboside raised NAD levels, helped reduce stiffness in the aorta and lowered systolic blood pressure in adults at risk of high blood pressure (22).

That said, more human research is needed.

Other Benefits

 It’s useful to note that nicotinamide riboside can reduce inflammation and oxidative stress. There are also nicotinamide riboside cancer benefits as well. Studies show NR can reduce tumor growth and protects DNA synthesis within cancer patients.

All of this culminates in general longevity and antiaging advantages. The byproduct of NR helps reprogram dysfunctional cells, which rejuvenate and enhance overall cell function. Because our cell function starts to decrease with age, this is a method of improving lifespan and quality of life.

There are a host of nicotinamide riboside benefits for the brain specifically. There are over 5 million Americans struggling with Alzheimer’s disease, which is the 6th highest cause of death. One 3 month study found that nicotinamide riboside could increase cognition and slow the progression of Alzheimer’s disease.

A separate study showed that nicotinamide riboside (NR) could delay the death of brain cells, which suggest a neuroprotective effect.

Anyone considered elderly can find nicotinamide riboside benefits almost immediately, but young healthy adults can as well.

The foundational strength of our brain is a small part of each cell called the mitochondria.   Natural Biology's product OxyAGE is all about the mitochondria.  When we use cognitive enhancers and nootropics that improve mitochondrial health, we can increase our energy and increase our resilience and longevity. That is the key of nicotinamide riboside, which has a wide variety of benefits.

Popular among biohacking communities, nicotinamide riboside (NR) increases the health of our mitochondria (the powerhouses of each cell). Similar to CoQ10 and PQQ, nicotinamide riboside supplements can boost both physical and cognitive function. NR has a preserving effect on neurons suggest neuroprotective capabilities.

The same mechanism of nicotinamide riboside can also enhance cognition and reduce symptoms of Alzheimer’s disease in animal models [3]. As with many foundational nootropics, the nicotinamide benefits come with few side effects.

Thoughts on Nicotinamide Riboside

Anything that improves mitochondrial function and is safe is a boom in Natural Biology's experience. 

If you do not consume any nootropics or stimulatory drugs, but and want to focus only on the options that can boost mitochondrial function or act as antioxidants, NR in OxyAGE & EVEREST Earth & Sea Formula is a great option.